MagnaRx pills to improve the male genitals - Makes the penis able to erect itself greater, maximizes the sexual drive, makes the erections more stable, harder and more durable, helps a man produce more abundant semen with better consistence, and strengthens the orgasms.  

Buy clicking at this banner, you will enter a page that can guide you to the products most fit for your own needs,  based on characteristics of your own sexual life and your  whishes for sexual life changes.

These products contain ginseng or other herbs. Please go to the web-site to see the products and their ingredients.

Items to improve health

Click here to find the right product

PRODUCTS to prevent, reduce or cure skin aging and skin problems - Products for prevention or cure of skin conditions or to ammeliorate symptoms of cronoic skin diseases: Aging symptoms of the skin, scne, scars, rashes, sun-damage, cellulites, thin skin, edema, miscolored skin, rosacea, psoriasis, etc

PRODUCTS FOR PREVENTION, CURE OR SUPPORT - Many topical medicines: - Many diseases respond to topical treatment, as well as to medicines taken by mouth, especially skin conditions and rheumatic ailments. Sometimes there is a need to combine systemic and topical treatment. Here you find many good topical remedies and also some systemic ones.

To find more innovative medicines

More cosmetic products

Natural products to prevent disease

phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina.

The phosphodiesterase (PDE) isozymes, found in several tissues including the rod and cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis.(1,2)

The interest in PDEs as molecular targets of drug action has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side effects attributed to nonselective inhibitors such as theophylline.(3,4)

A PDE5 inhibitor that is significantly more potent and selective than zaprinast (an early PDE5 inhibitor) and comparable in its PDE inhibitory properties to sildenafil (Viagra, 1998), a drug recently approved for the treatment of male erectile dysfunction.

PDE5 is an enzyme that accepts cGMP and breaks it down. The kinetics of binding [3H]sildenafil and [3H]tadalafil to the catalytic site of PDE5.

Both inhibitors bind with high affinity and specificity, and cGMP binding to the allosteric sites stimulates binding of PDE5 inhibitors at the catalytic site. The kinetics of inhibitor binding and inhibition of catalysis imply the existence of two PDE5 conformers, and results of native gel electrophoresis reveal that PDE5 exists in two apparently distinct conformations, i.e., an extended conformer and a more compact conformer.

PDE5 activity is modulated by a rapidly reversible redox switch. Chemical reduction of PDE5 relieves autoinhibition of enzyme functions; allosteric cGMP-binding activity is increased 10-fold, and catalytic activity is increased ~3-fold. The redox effect on allosteric cGMP-binding occurs in the isolated regulatory domain. A change in the state of reduction of PDE5 or the isolated regulatory domain is associated with an apparent conformational change similar to that caused by phosphorylation.

PDE5 is expressed in human colonic cells and in intestinal tissue and its activity is regulated by intracellular cGMP levels in these cells that increase on GCC activation. This presumably occurs through binding of cGMP to the GAF domains in the N-terminus of PDE5, resulting in allosteric activation of the enzyme.

The mechanism of action of E4021 on both the nonactivated and activated forms of rod PDE6 because both states are relevant to understanding how PDE5-selective inhibitors may alter signal transduction pathways in photoreceptor cells. PDE5-selective inhibitors may show good discrimination of PDE5 from most other PDE isoforms.

(The text is mostly from wikipedia.org and is therefore free to reuse)

Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP, most notably by activating intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface.

cGMP synthesis is catalyzed by guanylate cyclase (GC), which converts GTP to cGMP. Membrane-bound GC is activated by peptide hormones such as the atrial natriuretic factor, while soluble GC is typically activated by nitric oxide to stimulate cGMP synthesis.
cGMP is a common regulator of ion channel conductance, glycogenolysis, and cellular apoptosis. It also relaxes smooth muscle tissues. In blood vessels, relaxation of vascular smooth muscles lead to vasodilation and increased blood flow.

cGMP is a secondary messenger in phototransduction in the eye. In the photoreceptors (rods and cones) of the human eye, the absence of light activates phosphodiesterase, which upregulates cGMP by catalyzing its conversion from guanosine monophosphate (GMP). cGMP opens sodium ion channels, which leads to the depolarization of the photoreceptor's plasma membrane, which opens calcium ion channels, which leads to the release of neurotransmitters by the photoreceptor cell, which in turn signals other cells inbedded in the retina and leads to the transfer of information from the eye to the brain and vision.
 

Cyclic nucleotide phosphodiesterases (PDE 1-6) breakes down cGMP by hydrolyzing cGMP into 5'-GMP.

Phosphodiesterase inhibitors prevent the breaksown of cGMP, thereby enhancing and/or prolonging its effects. For example, Sildenafil (Viagra) enhances the vasodilatory effects of cGMP within the corpus cavernosum by inhibiting PDE 5 (or PDE V). This is used as a treatment for erectile dysfunction.

(The text is mostly from wikipedia.org and is therefore free to reuse)